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oai:i-rep.emu.edu.tr:11129/26642016-05-20T19:10:57Zhdl_11129_459Abureesh, Mosab AliOladipo, Akeem AdeyemiGazi, Mustafa2016-05-20T19:10:57Z2015-05-06Abureesh MA, Oladipo AA, Gazi M “ Facile synthesis of glucose-sensitive-poly(vinyl alcohol) hydroge: drug release optimization and swelling properties” International journal of Biological Macromolecules DOI:10.1016/j.ijbiomac.2015.10.0010141-8130 (print)1879-0003 (online)http://dx.doi.org/10.1016/j.ijbiomac.2015.10.001http://hdl.handle.net/11129/2664Due to copyright restrictions, the access to the publisher version (published version) of this article is only available via subscription. You may click URI and have access to the Publisher Version of this article through the publisher web site or online databases, if your Library or institution has subscription to the related journal or publication.The study describes the development of glucose-sensitive hydrogel and optimization of bovine serum albumin release profile from the hydrogel. To enhance the glucose sensitivity and improve the swelling behaviors ofthe hydrogel system, boric acid crosslinking, and freeze-thawing cycle techniques were used to prepare chitosan–poly(vinyl alcohol) hydrogel. The structure of the resultant hydrogel was confirmed
by scanning electron microscopy and Fourier transform infrared spectroscopy. The experimental results revealed that the swelling of the hydrogel was influenced by the pH of the medium, and the hydrogel displayed explicit glucose-sensitivity under physiological conditions. The values of the diffusion exponent range between 0.34 and 0.44 and the diffusion of water into the gel system are assumed to be pseudo-Fickian in nature. Under optimized conditions, the cumulative Bovine serum albumin (BSA) drug releases ranged between 69.33 ± 1.95% and 86.45 ± 1.16% at 37 ◦C in the presence of glucose and pH 7.4, respectively.engElsevier10.1016/j.ijbiomac.2015.10.001info:eu-repo/semantics/closedAccessChitosanPVAGlucose response hydrogelsDrug releaseOptimizationFacile synthesis of glucose-sensitive chitosan–poly(vinyl alcohol) hydrogel: Drug release optimization and swelling propertiesarticleInternational Journal of Biological MacromoleculesEastern Mediterranean University, Faculty of Art and Science, Department of ChemistryTR21657816Department of Chemistry08 Faculty of Arts and SciencesCHEM – Journal Articles: Pre-Prints (Pre-Refereeing Author Versions) – Chemistry