Hydrogels of Chitosan-graft-Poly(diethylamino ethyl methacrylate)

dc.contributor.advisor	Yalınca, Zulal (Co-Supervisor)
dc.contributor.advisor	Yılmaz, Elvan (Supervisor)
dc.contributor.author	Sirotina, Uliana
dc.date.accessioned	2018-06-14T07:00:49Z
dc.date.available	2018-06-14T07:00:49Z
dc.date.issued	2015-09
dc.date.submitted	2015-09
dc.identifier.citation	Sirotina, Uliana. (2015). Hydrogels of Chitosan-graft-Poly(diethylamino ethyl methacrylate). Thesis (M.S.), Eastern Mediterranean University, Institute of Graduate Studies and Research, Dept. of Chemistry, Famagusta: North Cyprus.	en_US
dc.identifier.uri	http://hdl.handle.net/11129/3771
dc.description	Master of Science in Chemistry. Thesis (M.S.)--Eastern Mediterranean University, Faculty of Arts and Sciences, Dept. of Chemistry, 2015. Co-Supervisor: Dr. Zulal Yalınca, Supervisor: Prof. Dr. Elvan Yılmaz.	en_US
dc.description.abstract	Poly(diethylamino) ethyl methacrylate, poly(DEAEM), was grafted onto chitosan, CH, under homogenous and heterogeneous conditions by using potassium persulphate, KPS, as the initiator to obtain pH responsive copolymers. The product, soluble in aqueous solution, was crosslinked with glutaraldehyde, GA. Gelation times of GA crosslinked CH and GA crosslinked CH-graft-poly(DEAEM) gels were experimentally found, and their swelling properties in aqueous solution were followed. Obtained samples were characterized by Scanning Electron Microscopy (SEM) analysis and FT-IR analysis. CH-TPP beads were prepared by coagulating CH in acetic acid solution in aqueous tripolyphosphate, TPP, solution. Then the beads were grafted by poly(DEAEM) by redox initiation. The antibiotic ciprofloxacin was loaded into the gel and drug release from CH-TPP beads and CH-TPP-graft-poly(DEAEM) beads was investigated. Keywords: chitosan gel, copolymerization, drug release, smart polymer	en_US
dc.description.abstract	ÖZ : Poly(dietilamino) etil metakrilat, poli(DEAEM), kitosan (CH) üzerine homojen ve heterojen ortamda potasyum persülfat (KPS) redoks başlatıcı kullanılarak aşılanmıştır. Bu yöntemle pH’a duyarlı kopolimerler elde etmek amaçlanmıştır. Asitli sulu çözeltide çözünen kopolimer glutaraldehit (GA) çapraz bağlayıcı ile reaksiyona sokularak hidrojeller elde edilmiştir. GA-CH ve GA-CH-aşı-poli(DEAEM) örneklerinin GA ile çapraz bağlanmak suretiyle jelleşme süreleri ölçülerek birbirleriyle karşılaştırılmıştır. Elde edilen jellerin sulu asitli, nötral ve bazik sulu ortamda şişme davranışları incelenmiştir. Örnekler taramalı electron mikroskobu (SEM) ve FTIR töntemleri ile karakterize edilmiştir. CH-TPP jel boncuklar kitosanın sodium tripolifosfat çözeltisi içinde koagülasyonu ile elde edilerek poli(DEAEM) aşılanarak modifiye edilmiştir. Elde edilen örnekler yukarda analtıldığı gibi karakterize edilmiş ve siprofloksasin yüklenerek sistemin ilaç salım davranışı incelenmiştir. Anahtar Kelimeler: kitosan jel, kopolimerizasyon, ilaç salımı, akıllı polimer	en_US
dc.language.iso	eng	en_US
dc.publisher	Eastern Mediterranean University (EMU) - Doğu Akdeniz Üniversitesi (DAÜ)	en_US
dc.rights	info:eu-repo/semantics/openAccess	en_US
dc.subject	Chemistry	en_US
dc.subject	chitosan gel	en_US
dc.subject	copolymerization	en_US
dc.subject	drug release	en_US
dc.subject	smart polymer	en_US
dc.title	Hydrogels of Chitosan-graft-Poly(diethylamino ethyl methacrylate)	en_US
dc.type	masterThesis	en_US
dc.contributor.department	Eastern Mediterranean University, Faculty of Arts and Sciences, Dept. of Chemistry	en_US