Qualitative Analysis of Cancer Pathways with Transition and Place Invariants

EMU I-REP

Show simple item record

dc.contributor.advisor Bashirov, Rza
dc.contributor.author Ngandjoug, Guy Romaric Yemeli
dc.date.accessioned 2021-11-08T13:28:25Z
dc.date.available 2021-11-08T13:28:25Z
dc.date.issued 2019
dc.date.submitted 2019-01
dc.identifier.citation Ngandjoug, Guy Romaric Yemeli. (2019).Qualitative Analysis of Cancer Pathways with Transition and Place Invariants. Thesis (M.S.), Eastern Mediterranean University, Institute of Graduate Studies and Research, Dept. of Mathematics, Famagusta: North Cyprus. en_US
dc.identifier.uri http://hdl.handle.net/11129/5179
dc.description Master of Science in Applied Mathematics and Computer Science. Thesis (M.S.)--Eastern Mediterranean University, Faculty of Arts and Sciences, Dept. of Mathematics, 2019. Supervisor: Prof. Dr. Rza Bashirov. en_US
dc.description.abstract It is of practical interest to know whether a biological network contains mass-preserving and state-preserving subnetworks. In a mass-preserving subnetwork, the total mass remains constant. In any state-preserving subnetwork, biological reactions bring the subnetwork back to an initial state. For instance, any reversible reaction forms a state-preserving subnetwork. In a large intricate biological network, it is rather cumbersome task to determine mass-preserving and state-preserving subnetworks. P-invariants and T-invariants are analysis methods that can be successfully used to determine mass-preserving and state-preserving subnetworks in a Petri net. In this thesis, the information is derived from the biological databases Reactome and KEGG as well as from the existing literature to date, to create rather detailed Petri net model of cancer pathway, and perform its qualitative analysis with P-invariants and T-invariants. Keywords: Biological network, Petri net, P-invariants, T-invariants. en_US
dc.description.abstract ÖZ: Bir biyolojik ağın kitle-koruyucu ve durum-koruyucu alt ağlar içerip içermediğini bilmenin pratik önemi vardır. Bir kitle-koruyucu alt ağda, toplam kitle sabittir ve bu nedenle sınırlıdır. Herhangi bir durumu koruyan alt ağda, biyolojik reaksiyonlar alt ağı bu duruma geri getirir. Örneğin, geri-dönüşümlü herhangi bir reaksiyon, durum koruyucu bir alt ağ oluşturur. Büyük ve karmaşık bir biyolojik ağda, kitle ve durum koruyucu alt ağları belirlemek oldukça zorlu bir iştir. P-invariantlar ve T-invariantlar, kitle koruyucu ve durum koruyucu alt ağların belirlenmesinde başarılı olabilen Petri net analiz yöntemleridir. Bu tezde, Reactome ve KEGG gibi biyolojik veri tabanlarından ve mevcut literatürden bilgi derleyerek kanser yollarnın ayrıntılı Petri ağı modeli oluşturulur ve bu modelin P-invariantlar ve T-invariantlar metodları ile nitel analizi yapılmıştır. Anahtar Kelimeler: Biyolojik ağda, Petri net, P-invariantlar, T-invariantlar. en_US
dc.language.iso eng en_US
dc.publisher Eastern Mediterranean University (EMU) - Doğu Akdeniz Üniversitesi (DAÜ) en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Mathematics en_US
dc.subject Applied Mathematics and Computer Science en_US
dc.subject Computational biology en_US
dc.subject Systems biology en_US
dc.subject Biological network en_US
dc.subject Petri net en_US
dc.subject P-invariants en_US
dc.subject T-invariants en_US
dc.title Qualitative Analysis of Cancer Pathways with Transition and Place Invariants en_US
dc.type masterThesis en_US
dc.contributor.department Eastern Mediterranean University, Faculty of Arts and Sciences, Dept. of Mathematics en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record