Browsing 08 Faculty of Arts and Sciences by Author "Tüzmen, Şükrü"

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Petri net based modelling and simulation of p16-Cdk4/6-Rb pathway

Çetin, İlke; Bashirov, Rza; Tüzmen, Şükrü (CEUR, 2013-06-24)

p16 is recognized as a tumor suppressor gene due to the prevalence of its genetic inactivation in all types of human cancers. Additionally, p16 gene plays a critical role in controlling aging, regulating cellular senescence, ...
Target based drug discovery for beta-globin disorders: Drug target prediction using quantitative modelling with hybrid functional Petri nets

Mehraei, Mani; Bashirov, Rza; Tüzmen, Şükrü (2016-01-18)

Recent molecular studies provide important clues into treatment of beta-thalassemia, sickle-cell anaemia and other beta-globin disorders revealing that increased production of fetal hemoglobin, that is normally suppressed ...
Validation of signaling pathways: case study of the p16-mediated pathway

Akçay, Nimet İlke; Bashirov, Rza; Tüzmen, Şükrü (Journal of Bioinformatics and Computational Biology, World Scientific Publishing, 2015)

p16 is recognized as a tumor suppressor gene due to the prevalence of its genetic inactivation in all types of human cancers. Additionally, p16 gene plays a critical role in controlling aging, regulating cellular senescence, ...