Browsing Department of Mathematics by Author "Mehraei, Mani"

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Exploiting Hybrid Functional Petri Nets to Investigate Transcriptional Activity of Hemoglobin Switching

Mehraei, Mani (Eastern Mediterranean University (EMU) - Doğu Akdeniz Üniversitesi (DAÜ), 2016-07)

β-thalassemia, SCD and other human β-globin gene related diseases are the major sources of mortality in the world. Bone marrow transplantation, gene therapy and supporting care with transfusion of red blood cells are ...
Identifying targets for gene therapy of β-globin disorders using quantitative modeling approach

Bashirov, Rza; Mehraei, Mani (Elsevier, 2017-08)

Sickle cell disease and β-thalassemia are well-known genetic disorders which are caused by mutations in β-globin gene. Reactivation of fetal hemoglobin in adulthood through induction of γ-globin gene expression has proven ...
Target based drug discovery for beta-globin disorders: Drug target prediction using quantitative modelling with hybrid functional Petri nets

Mehraei, Mani; Bashirov, Rza; Tüzmen, Şükrü (2016-01-18)

Recent molecular studies provide important clues into treatment of beta-thalassemia, sickle-cell anaemia and other beta-globin disorders revealing that increased production of fetal hemoglobin, that is normally suppressed ...