Browsing Department of Mathematics by Subject "Quantitative modeling"

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Exploiting Hybrid Functional Petri Nets to Investigate Transcriptional Activity of Hemoglobin Switching

Mehraei, Mani (Eastern Mediterranean University (EMU) - Doğu Akdeniz Üniversitesi (DAÜ), 2016-07)

β-thalassemia, SCD and other human β-globin gene related diseases are the major sources of mortality in the world. Bone marrow transplantation, gene therapy and supporting care with transfusion of red blood cells are ...
Identifying targets for gene therapy of β-globin disorders using quantitative modeling approach

Bashirov, Rza; Mehraei, Mani (Elsevier, 2017-08)

Sickle cell disease and β-thalassemia are well-known genetic disorders which are caused by mutations in β-globin gene. Reactivation of fetal hemoglobin in adulthood through induction of γ-globin gene expression has proven ...
Validation of signaling pathways: case study of the p16-mediated pathway

Akçay, Nimet İlke; Bashirov, Rza; Tüzmen, Şükrü (Journal of Bioinformatics and Computational Biology, World Scientific Publishing, 2015)

p16 is recognized as a tumor suppressor gene due to the prevalence of its genetic inactivation in all types of human cancers. Additionally, p16 gene plays a critical role in controlling aging, regulating cellular senescence, ...