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Browsing MAT – Journal Articles: Publisher & Author Versions (Post-Print Author Versions) – Mathematics by Subject "Hybrid functional Petri net"

Now showing items 1-2 of 2

Identifying targets for gene therapy of β-globin disorders using quantitative modeling approach

Bashirov, Rza; Mehraei, Mani (Elsevier, 2017-08)

Sickle cell disease and β-thalassemia are well-known genetic disorders which are caused by mutations in β-globin gene. Reactivation of fetal hemoglobin in adulthood through induction of γ-globin gene expression has proven ...
Validation of signaling pathways: case study of the p16-mediated pathway

Akçay, Nimet İlke; Bashirov, Rza; Tüzmen, Şükrü (Journal of Bioinformatics and Computational Biology, World Scientific Publishing, 2015)

p16 is recognized as a tumor suppressor gene due to the prevalence of its genetic inactivation in all types of human cancers. Additionally, p16 gene plays a critical role in controlling aging, regulating cellular senescence, ...