Synthesis, Characterization, of Antioxidant Activity Mannich Bases from 2-Benzoxalinones

Abstract

This study aimed to synthesize a series of 3-substituted piperazinomethyl derivatives (BzO1-4) via a Mannich reaction and evaluate their antioxidant activities using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and ferrous ion- chelation capacity assays. The synthesis process involved precise techniques, and the compounds were characterized using elemental analysis, FT-IR, and 1H-NMR spectroscopy. Notably, BzO-1, featuring a 4-methylphenyl substituent, emerged as a novel compound within this series, demonstrating the highest antioxidant activity among the four derivatives tested. A considarable performance of BzO-1 was evident in its ability to neutralize free radicals and ferric ion-chelating capacity indicating its potential as a potent antioxidant agent. The detailed characterization data provided insights into the molecular structures and electronic environments of the synthesized compounds, which were crucial for understanding their antioxidant mechanisms. These findings suggest that the structural modifications in these piperazinomethyl derivatives significantly influence their antioxidant properties, and the novel BzO-1 compound holds promise for further development and application in antioxidant therapy.