Comparative studies on Turkish and Indian Centella asiatica (L.) Urban (gotu kola) samples for their enzyme inhibitory and antioxidant effects and phytochemical characterization

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dc.contributor.authorOrhan, Ilkay Erdogan
dc.contributor.authorAtasu, Erdem
dc.contributor.authorSenol, Fatma Sezer
dc.contributor.authorOzturk, Nilgun
dc.contributor.authorDemirci, Betul
dc.contributor.authorDas, Kuntal
dc.contributor.authorSekeroglu, Nazim
dc.date.accessioned2026-02-06T18:39:35Z
dc.date.issued2013
dc.departmentDoğu Akdeniz Üniversitesi
dc.description.abstractIn this study, enzyme inhibitory and antioxidant activity of the ethanol extracts of Centella asiatica (L.) Urban from Turkey and India was examined and the results were compared to those of the standardized extract of the plant obtained from China. Inhibitory activity of these three extracts was screened against four enzymes; acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase (TYRO), and lipoxygenase (LOX) using ELISA microplate reader. Antioxidant activity of the extracts was determined in vitro using 2,2-diphenyl-1-picrylhydrazyl (DPPH), metal-chelation, and ferric-reducing antioxidant power (FRAP) assays. The extracts showed a notable inhibition against BChE and TYRO, while the extracts from Turkey and India displayed lower activity in the antioxidant assays. HPLC analysis indicated that the Turkish plant sample was found to be richest in p-hydroxy-benzoic acid, whilst the Indian sample contained chlorogenic acid in the most abundant amount. alpha-Copaene was the dominant compound in the essential oil of the plant sample from Turkey. (c) 2013 Elsevier B.V. All rights reserved.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)
dc.description.sponsorshipThe authors would like to thank to Phytopharma Drug and Herbal Health Products Ltd. (Ankara, Turkey) for kindly providing the standardized extract of CA imported from China. We also would like to acknowledge Zeytinburnu Medicinal Plant Garden (Istanbul, Turkey) for providing us with the plant material of CA. F.S. Senol would like to express her sincere thanks to the Scientific and Technological Research Council of Turkey (TUBITAK) for the scholarship provided for her Ph.D. program.
dc.identifier.doi10.1016/j.indcrop.2013.03.022
dc.identifier.endpage322
dc.identifier.issn0926-6690
dc.identifier.issn1872-633X
dc.identifier.orcid0000-0002-7379-5436
dc.identifier.orcid0000-0001-6118-5270
dc.identifier.orcid0000-0002-5850-9841
dc.identifier.orcid0000-0003-2343-746X
dc.identifier.scopus2-s2.0-84876882997
dc.identifier.scopusqualityQ1
dc.identifier.startpage316
dc.identifier.urihttps://doi.org/10.1016/j.indcrop.2013.03.022
dc.identifier.urihttps://hdl.handle.net/11129/12940
dc.identifier.volume47
dc.identifier.wosWOS:000319892000044
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofIndustrial Crops and Products
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260204
dc.subjectCentella asiatica
dc.subjectGotu kola
dc.subjectEnzyme inhibition
dc.subjectAntioxidant activity
dc.subjectPhenolic acid
dc.subjectEssential oil
dc.titleComparative studies on Turkish and Indian Centella asiatica (L.) Urban (gotu kola) samples for their enzyme inhibitory and antioxidant effects and phytochemical characterization
dc.typeArticle

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