Synthesis and Characterization of PolyHEMA Microparticels for Drug Release
| dc.contributor.advisor | Yılmaz, Elvan (Supervisor) | |
| dc.contributor.author | Alkum, Bahaeddin Emad Fahmi | |
| dc.date.accessioned | 2026-06-09T11:34:33Z | |
| dc.date.issued | 2023 | |
| dc.department | Fakülteler, Fen ve Edebiyat Fakültesi, Kimya Bölümü | |
| dc.description | Master of Science in Chemistry. Institute of Graduate Studies and Research. Thesis (M.S.) - Eastern Mediterranean University, Faculty of Arts and Sciences, Dept. of Chemistry, 2023. Supervisor: Prof. Dr. Elvan Yılmaz. | |
| dc.description.abstract | Poly(HEMA-co-EGDMA) microparticles were synthesized by using suspension polymerization at different ratios of the monomer, 2-hydroxy ethyl methacrylate (HEMA) and the crosslinker, ethylene glycol dimethacrylate (EGDMA) at 70 °C for 3 hours with stirring at 350 rpm. The redox couple ammonium persulfate (APS) and N,N,N',N-tetramethylene diamine (TEMED) was used as the initiator. Magnesium oxide (MgO) was used as the stabilizer. Ratios of monomer and crosslinkers were altered to synthesise different microbeads of poly(HEMA-co-EGDMA) with different crosslinking ratios. The swelling behaviour of the microparticles was analysed in three different buffer solutions: acetate buffer at pH 2.0, phosphate buffer at pH 7.4 and pH 11 at 37 °C. In addition, loading of flurbiprofen and methylene blue into the microparticles and their release characteristics were investigated. Drug loaded and unloaded samples were analysed by FT-IR spectroscopy and scanning electron microscopy (SEM). Keywords: Poly(HEMA-co-EGDMA), Microbead, Copolymer, Flurbiprofen, Methylene Blue, Controlled Release, HEMA, EGDMA. | |
| dc.description.abstract | Bu çalışmada, süspansiyon polimerizasyon yöntemi kullanılarak poli(HEMA-koEGDMA) mikroparçacılar değişik monomer:çapraz bağlayıcı oranları ile sentezlendi. Monomer, 2-hidroksi etil metakrilat (HEMA) ve çapraz bağlayıcı, etilen glikol dimetakrilat (EGDMA) ile redoks başlatıcı çifti amonyum persülfat (APS) ve N,N,N',N-tetrametilen diamin (TEMED) sulu ortamda 350 rmp süratle karıştırılarak 70 °C'ta 3 saatte polimerleştirildi. Magnezyum oksit (MgO) stabilizatör olarak kullanıldı. Mikroparçacıkların şişme davranışları pH 2, pH 7.4 ve pH 11 tampon çözeltilerde 37 °C sıcaklıkta izlendi. Sentezlenen poli(HEMA-ko-EGDMA) mikroparçacıkların flurbiprofen ve metilen mavisi model madde olarak kullanılarak hidrofobik ve hidrofilik ilaçlar için kontrollu salım sistemi olarak davranabilme potansiyelleri incelendi. Sentezlenen örnekler FTIR spektroskopisi ve SEM analizi ile karakterize edildi. Anahtar Kelimeler: Poly(HEMA-ko-EGDMA), Mikro Boncuk, Kopolimer, Flürbiprofen, Metilen Mavisi, Kontrollu Salım, HEMA, EGDMA. | |
| dc.identifier.citation | Alkum, Bahaeddin Emad Fahmi. (2023). Synthesis and Characterization of PolyHEMA Microparticels for Drug Release. Thesis (M.S.), Eastern Mediterranean University, Institute of Graduate Studies and Research, Dept. of Chemistry, Famagusta: North Cyprus. | |
| dc.identifier.uri | https://hdl.handle.net/11129/15972 | |
| dc.language.iso | en | |
| dc.publisher | Eastern Mediterranean University | |
| dc.relation.publicationcategory | Tez | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | Thesis Tez | |
| dc.subject | Chemistry Department | |
| dc.subject | Polymerization | |
| dc.subject | Poly(HEMA-co-EGDMA) | |
| dc.subject | Microbead | |
| dc.subject | Copolymer | |
| dc.subject | Flurbiprofen | |
| dc.subject | Methylene Blue | |
| dc.subject | Controlled Release | |
| dc.subject | HEMA | |
| dc.subject | EGDMA. | |
| dc.title | Synthesis and Characterization of PolyHEMA Microparticels for Drug Release | |
| dc.type | Master Thesis |
