Evaluation of Tetrahydrobiopterin Pathway in Operating Room Workers: Changes in Biopterin Status and Tryptophan Metabolism

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dc.contributor.authorBaydar, Mustafa
dc.contributor.authorCapan, Zeynep
dc.contributor.authorGirgin, Gozde
dc.contributor.authorPalabiyik, S. Sezin
dc.contributor.authorSahin, Gonul
dc.contributor.authorFuchs, Dietmar
dc.contributor.authorBaydar, Terken
dc.date.accessioned2026-02-06T18:34:01Z
dc.date.issued2012
dc.departmentDoğu Akdeniz Üniversitesi
dc.description.abstractThe aim of the study was to evaluate the effect of anesthetics as operating room contaminants on tetrahydrobiopterin pathway in 40 operating room personnel and 30 healthy controls by measuring biopterin, dihydrobiopterin reductase, tryptophan, kynurenine and serotonin. Biopterin concentrations were 124 +/- A 12.3 A mu mol/mol creatinine in workers and 88 +/- A 5.7 A mu mol/mol creatinine in controls whereas kynurenine concentrations were 1.75 +/- A 0.09 A mu M and 1.95 +/- A 0.06 A mu M, respectively (both, p < 0.05). It can be claimed that enhanced biopterin and diminished kynurenine levels may play a triggering role in disruption of metabolic events in operating room personnel.
dc.identifier.doi10.1007/s00128-012-0845-y
dc.identifier.endpage1128
dc.identifier.issn0007-4861
dc.identifier.issue6
dc.identifier.orcid0000-0003-3742-6841
dc.identifier.orcid0000-0002-5497-9600
dc.identifier.orcid0000-0002-9333-7213
dc.identifier.orcid0000-0002-6239-6114
dc.identifier.pmid23052583
dc.identifier.scopus2-s2.0-84870924984
dc.identifier.scopusqualityQ2
dc.identifier.startpage1125
dc.identifier.urihttps://doi.org/10.1007/s00128-012-0845-y
dc.identifier.urihttps://hdl.handle.net/11129/11595
dc.identifier.volume89
dc.identifier.wosWOS:000310867400005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofBulletin of Environmental Contamination and Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260204
dc.subjectTetrahydrobiopterin
dc.subjectTryptophan
dc.subjectKynurenine
dc.subjectOperating room personnel
dc.titleEvaluation of Tetrahydrobiopterin Pathway in Operating Room Workers: Changes in Biopterin Status and Tryptophan Metabolism
dc.typeArticle

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