A mechanistic investigation on anticholinesterase and antioxidant effects of rose (Rosa damascena Mill.)

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dc.contributor.authorSenol, Fatma Sezer
dc.contributor.authorOrhan, Ilkay Erdogan
dc.contributor.authorKurkcuoglu, Mine
dc.contributor.authorKhan, Mahmud Tareq Hassan
dc.contributor.authorAltintas, Ayten
dc.contributor.authorSener, Bilge
dc.contributor.authorBaser, Kemal Husnu Can
dc.date.accessioned2026-02-06T18:38:10Z
dc.date.issued2013
dc.departmentDoğu Akdeniz Üniversitesi
dc.description.abstractIn the current study, neuroprotective effect of the essential oil and aromatic waters of rose was investigated by in vitro and in silico methods. The samples were tested for their inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Since oxidative damage is associated with neurodegeneration, antioxidant activity of the samples was determined by DPPH radical scavenging, metal-chelation, and ferric-reducing antioxidant power (FRAP) assays. Their chemical composition was elucidated by GC-MS. Anti-cholinesterase effects of the main components (citronellol, geraniol, nerol, and phenylethyl alcohol) were also examined. The rose oil showed a noteworthy inhibition against AChE (60.86 +/- 1.99%) and BChE (51.08 +/- 1.70%) at 1000 mu g/mL and low activity in DPPH radical scavenging and FRAP tests. Phenylethyl alcohol exerted higher cholinesterase inhibition than other components and applied further to molecular docking simulations. Docking and binding energies supporting experimental results show that the compound is more selective towards BChE than AChE. (C) 2013 Elsevier Ltd. All rights reserved.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)
dc.description.sponsorshipF.S. Senol expresses her sincere gratefulness to the Scientific and Technological Research Council of Turkey (TUBITAK) for the scholarship provided for Ph.D. program. The authors also would like to thank IFF (International Flavors & Fragrances Inc., NY, USA) for providing the reference samples of (-)-beta-citronellol, (+)-beta-citronellol, geraniol, nerol, and phenylethyl alcohol used in this study as a courtesy. M.T.H. Khan is grateful to Prof. Ingebrigt Sylte (Department of Medical Biology, Faculty of Health Science, University of Tromso, Norway) for the access of the license of ICM-Pro version.
dc.identifier.doi10.1016/j.foodres.2013.05.031
dc.identifier.endpage509
dc.identifier.issn0963-9969
dc.identifier.issue1
dc.identifier.orcid0000-0002-7379-5436
dc.identifier.orcid0000-0003-2710-0231
dc.identifier.orcid0000-0002-5850-9841
dc.identifier.scopus2-s2.0-84879519339
dc.identifier.scopusqualityQ1
dc.identifier.startpage502
dc.identifier.urihttps://doi.org/10.1016/j.foodres.2013.05.031
dc.identifier.urihttps://hdl.handle.net/11129/12794
dc.identifier.volume53
dc.identifier.wosWOS:000323239400061
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.ispartofFood Research International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260204
dc.subjectRose
dc.subjectCholinesterase inhibition
dc.subjectAntioxidant activity
dc.subjectMolecular docking
dc.subjectPhenylethyl alcohol
dc.titleA mechanistic investigation on anticholinesterase and antioxidant effects of rose (Rosa damascena Mill.)
dc.typeArticle

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