NTreceptorDB: a Database of Polymorphisms and Disease-Gene Associations in Behavioral Disorders

Abstract

Genetic variation in neurotransmitter receptors have been shown to be associated with various behavioral and mental disorders. Presentation of disease-neurotransmitter receptor relationship in a comprehensive manner would prove useful for future experimental as well as computational work. In this study, we approach the relationship of neurotransmitter receptors to mental and behavioral disorders from a biomedical text mining perspective. To this extent, we collected an initial set of known neurotransmitter receptors and mental disorders, and built an association by automated literature and text mining methods using Support Vector Machines. NTreceptorDB, a database that enables users to analyze association between neurotransmitter receptor and mental disorder data is developed. Abstracts available in NTreceptorDB show biomedical evidence for neurotransmitter receptor-disease association and are linked to PubMed. In particular, NTreceptorDB covers specific polymorphisms in neuro-transmitter receptor genes that are associated with diseases.