CHEMICAL COMPOSITION AND ANTI-INFLAMMATORY ACTIVITY OF KITAIBELIA BALANSAE BOISS

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dc.contributor.authorKaratoprak, Gokce Seker
dc.contributor.authorPasayeva, Leyla
dc.contributor.authorSafak, Esra Kongul
dc.contributor.authorGoger, Fatih
dc.contributor.authorTugay, Osman
dc.contributor.authorKosar, Muberra
dc.date.accessioned2026-02-06T18:23:47Z
dc.date.issued2019
dc.departmentDoğu Akdeniz Üniversitesi
dc.description.abstractAerial part extracts of Kitaibelia balansae Boiss. were examined for their phenolic contents, as well as anti-inflammatory activities. The chemical compositions of the extracts were analysed by spectrophotometric and chromatographic (HPLC/ MS/MS and HPLC-PDA) approaches. To measure anti-inflammatory activity, the effects of the extracts on nitric oxide (NO) and Tumour Necrosis Factor-alpha (TNF-alpha) levels were measured in lipopolysaccharide (LPS) treated murine macrophage cell line (RAW 264.7). The ethyl acetate fraction was found to be abundant in phenolic compounds (259.78 +/- 15.07 mg(GAE)/gextract). Rutin was identified as the major compound in all the extracts. The ethyl acetate fraction potentially inhibited NO and TNF-alpha production (37.26 mu M and 1781.524 pg/mL, respectively, 6 h) in LPS induced cells.
dc.description.sponsorshipErciyes University Scientific Research Projects [THD-2016-6600]
dc.description.sponsorshipErciyes University Scientific Research Projects (THD-2016-6600) supported this research.
dc.identifier.doi10.31925/farmacia.2019.6.17
dc.identifier.endpage1059
dc.identifier.issn0014-8237
dc.identifier.issn2065-0019
dc.identifier.issue6
dc.identifier.orcid0000-0003-4775-6860
dc.identifier.orcid0000-0002-9665-0256
dc.identifier.orcid0000-0003-3860-7222
dc.identifier.orcid0000-0003-3980-7648
dc.identifier.scopus2-s2.0-85077182133
dc.identifier.scopusqualityQ3
dc.identifier.startpage1054
dc.identifier.urihttps://doi.org/10.31925/farmacia.2019.6.17
dc.identifier.urihttps://hdl.handle.net/11129/9892
dc.identifier.volume67
dc.identifier.wosWOS:000510208600017
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSoc Stiinte Farmaceutice Romania
dc.relation.ispartofFarmacia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260204
dc.subjectKitaibelia balansae
dc.subjectMalvaceae
dc.subjectHPLC/MS/MS
dc.subjectanti-inflammatory
dc.titleCHEMICAL COMPOSITION AND ANTI-INFLAMMATORY ACTIVITY OF KITAIBELIA BALANSAE BOISS
dc.typeArticle

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