Cytotoxic activity and antioxidant effects of Origanum onites essential oil and its two major contents, carvacrol and p-cymene on human colorectal (HCT116) and hepatocelluler carcinoma (HepG2) cell lines

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dc.contributor.authorBecer, Eda
dc.contributor.authorAltundag, Ergul Mutlu
dc.contributor.authorBaser, K. Husnu Can
dc.contributor.authorVatansever, Hafize Seda
dc.date.accessioned2026-02-06T18:46:58Z
dc.date.issued2022
dc.departmentDoğu Akdeniz Üniversitesi
dc.description.abstractOriganum onites L. (O. onites) is one of the cultivated Origanum species in Turkey. The aim of this study was to determine the cytotoxicity and cellular antioxidant effects of O. onites essential oil, carvacrol and p-cymene on HCT116 and HepG2 cells. O. onites essential oil components were analyzed by GC/MS and GC/FID. Cytotoxicity was analyzed via the MTT assay in HCT116 and HepG2 cells. Cellular antioxidant activities of O. onites essential oil, carvacrol and p-cymene were determined with DCFH-DA method. GC/MS analysis identified carvacrol (%78.4) as the main constituent of O. onites essential oil. 400 mu g/ml concentration of O. onites essential oil, carvacrol and p-cymene were found to be active against HCT116 and HepG2 cells. Also, carvacrol showed higher cellular antioxidant activity than O. onites essential oil and p-cymene. We conclude that O. onites essential oil and carvacrol may be a candidate for pharmaceutical products in treatment of cancer.
dc.identifier.doi10.1080/10412905.2022.2107101
dc.identifier.endpage523
dc.identifier.issn1041-2905
dc.identifier.issn2163-8152
dc.identifier.issue6
dc.identifier.orcid0000-0003-2710-0231
dc.identifier.scopus2-s2.0-85136964188
dc.identifier.scopusqualityQ2
dc.identifier.startpage514
dc.identifier.urihttps://doi.org/10.1080/10412905.2022.2107101
dc.identifier.urihttps://hdl.handle.net/11129/14147
dc.identifier.volume34
dc.identifier.wosWOS:000839453200001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofJournal of Essential Oil Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260204
dc.subjectOriganum onites L
dc.subjectessential oil
dc.subjectcarvacrol
dc.subjectp-cymene
dc.subjectcancer
dc.subjectantioxidant
dc.titleCytotoxic activity and antioxidant effects of Origanum onites essential oil and its two major contents, carvacrol and p-cymene on human colorectal (HCT116) and hepatocelluler carcinoma (HepG2) cell lines
dc.typeArticle

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