In vitro cholinesterase, lipoxygenase inhibition evaluation of rosemary and coriander essential oil nanoemulsion and characterisation

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dc.contributor.authorKaraca, Nursenem
dc.contributor.authorDemirci, Fatih
dc.date.accessioned2026-02-06T18:38:12Z
dc.date.issued2024
dc.departmentDoğu Akdeniz Üniversitesi
dc.description.abstractIntroduction: The low water solubility, high volatility, and instability of essential oils limit the application of various formulations, which can be managed by essential oils nanoemulsions. In this present study, in vitro antiinflammatory and anticholinesterase activities were evaluated by designing nanoemulsions of rosemary and coriander essential oils with their combinations. Methods: The chemistry of Rosmarinus officinalis L. (Rosemary, Lamiaceae) and Coriandrum sativum L. (Coriander, Apiaceae) essential oils was confirmed by GC-FID and GC/MS methods. Oil-in-Water (O/W) emulsions of essential oils and their 1:1 (w:w) combination were prepared by water titration. The essential oil/tween 20 ratio of the emulsions were 1:9, 2:8, and 3:7 (w:w) respectively. Characterisation studies were performed by measuring the droplet size, polydispersity index (PDI), zeta potential, and viscosity of the emulsions. Also, resistance to centrifugation, freezing, and heating was determined as part of the stability tests. Anti-inflammatory effects of the essential oils and emulsions were determined by in vitro 5-Lipoxygenase (LOX) inhibition. In addition, in vitro Acetylcholinesterase and Butyrylcholinesterase (AChE and BuChE) effects were evaluated. Results: The rosemary (1,8-cineole; 44.1%), coriander (linalool; 74.9%) essential oils, and their nanoemulsion formulations prepared were observed as stable. The anti-inflammatory activity of coriander essential oil was relatively increased by nanoemulsion preparations. However, there was no significant difference in the cholinesterase inhibition effects, when compared. To the best of our knowledge this is the first combination study of bioactivity evaluation of rosemary and coriander nanoemulsion preparations. Conclusion: Rosemary and coriander essential oil nano emulsifications is a promising application for increasing stability and biological activity as well.
dc.description.sponsorshipAnadolu University Scientific Research Projects [BAP 1604S160, 10444066]
dc.description.sponsorshipThis work was supported by the Anadolu University Scientific Research Projects (BAP 1604S160), which is also part of the Ph.D. study of N. Karaca (No: 10444066). The authors would like to thank the Pharmaceutical Technology Department, ESOGU-ARUM for instrumental analysis support, and Prof. Dr. Betuel Demirci for the detailed Chromatographic analyses. The authors would like to dedicate this work to the late emeritus Prof. Dr. Kas & imath;m Cemal GUEVEN of Pharmaceutical Technology and Natural Product Chemistry, who passed away in Istanbul on the 25th of September 2020.
dc.identifier.doi10.1016/j.hermed.2024.100874
dc.identifier.issn2210-8033
dc.identifier.issn2210-8041
dc.identifier.orcid0000-0003-1497-3017
dc.identifier.scopus2-s2.0-85190501797
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.hermed.2024.100874
dc.identifier.urihttps://hdl.handle.net/11129/12824
dc.identifier.volume45
dc.identifier.wosWOS:001298469800001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Gmbh
dc.relation.ispartofJournal of Herbal Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260204
dc.subjectNanoemulsion
dc.subjectRosemary
dc.subjectCoriander
dc.subjectEssential oil
dc.subjectLipoxygenase
dc.subjectCholinesterase
dc.titleIn vitro cholinesterase, lipoxygenase inhibition evaluation of rosemary and coriander essential oil nanoemulsion and characterisation
dc.typeArticle

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